Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target
Tatiana P Soares da Costa, Sebastien Desbois, Con Dogovski, Michael A Gorman, Natalia E Ketaren, Jason J Paxman, Tanzeela Siddiqui, Leanne M Zammit, Belinda M Abbott, Roy M Robins-Browne, Michael W Parker, Geoffrey B Jameson, Nathan E Hall, Santosh Panjikar, Matthew A Perugini
Structure | CELL PRESS | Published : 2016
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council of Australia
We would firstly like to acknowledge the support and assistance of the friendly staff at the CSIRO Collaborative Crystallisation Center (www.csiro.au/C3), Melbourne, Australia, and the beamline scientists at the Australian Synchrotron, VIC, Australia. We would also like to thank Prof. Elizabeth Hartland (Department of Microbiology and Immunology, The University of Melbourne) for providing genomic DNA from L. pneumophila and A/Prof. Geoffrey Hogg (Microbiological Diagnostic Unit, University of Melbourne, Public Health Laboratory Network, Department of Health and Aging, Australia) for providing genomic DNA from S. pneumoniae. M.A.P. and S.P. acknowledge the Australian Research Council for funding support (DP150103313), and T.P.S.C. and M.W.P. the National Health and Medical Research Council of Australia for fellowship support (APP1091976 and APP1021645). J.J.P. was funded by an Australian Synchrotron fellowship. Funding from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute is acknowledged. We would also like to acknowledge the La Trobe University-Comprehensive Proteomics Platform for providing infrastructure and expertise. Finally, we thank all members of the Perugini laboratory for helpful discussions during the preparation of the manuscript.