Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Grants

Funding Acknowledgements

This research was partly undertaken on the MX2 beamline at the Australian Synchrotron, Victoria, Australia, and we thank the beamline staff for their assistance. We thank and acknowledge the use of the CSIRO Collaborative Crystallisation Centre (C3), Melbourne, Australia for our initial crystallization studies. We thank Dene Littler for his contributions to the structural studies, Joanna Woodcock for helpful discussions, and Anna Sapa for technical assistance. This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) to T.R.H., M.W.P., and A.F.L., and from the Australian Cancer Research Foundation to M.W.P. Funding from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute is acknowledged. S.E.B. is a Postdoctoral Fellow supported by the Leukaemia Foundation. U.D. and M.W.P. are NHMRC Postdoctoral and Research Fellows, respectively.