Journal article

Is breast cancer risk associated with alcohol intake before first full-term pregnancy?

Harindra Jayasekara, Robert J MacInnis, Allison M Hodge, Robin Room, Roger L Milne, John L Hopper, Graham G Giles, Dallas R English



PURPOSE: It is plausible that breast tissue is particularly susceptible to carcinogens, including ethanol, between menarche and the first full-term pregnancy ("first pregnancy"). There is some epidemiological evidence that intake before the first pregnancy is more closely associated with risk of breast cancer than is intake thereafter. We examined this association using lifetime alcohol consumption data from a prospective cohort study. METHODS: We calculated usual alcohol intake for age periods 15-19 years and for 10-year period from age 20 to current age (in grams per day) using recalled frequency and quantity of beverage-specific consumption for 13,630 parous women who had their first preg..

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Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council Grants 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria. JLH is a National Health and Medical Research Council Senior Principal Research Fellow. RR's position was funded by the Victorian Department of Health and the Foundation for Alcohol Research and Education. The funding sources played no role in the study design, in the collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.