Cell death is not essential for caspase-1-mediated interleukin-1 beta activation and secretion

SA Conos; KE Lawlor; DL Vaux; JE Vince; LM Lindqvist

Journal article

Cell death is not essential for caspase-1-mediated interleukin-1 beta activation and secretion

SA Conos, KE Lawlor, DL Vaux, JE Vince, LM Lindqvist

Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/cdd.2016.69

University of Melbourne Researchers

Kate Lawlor Author Medical Biology (W.E.H.I.)

David Vaux Author Medical Biology (W.E.H.I.)

James Vince Author Medical Biology (W.E.H.I.)

Lisa Lindqvist Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research (Canberra, Australia)

Awarded by Victorian State Government OIS

Funding Acknowledgements

We thank W Cook and J Silke (WEHI) for vectors, M Rashidi (WEHI) for NF-kappa B Thp1 reporter cells, K Schroder (IMB) for the pMIGR retroviral vector and R Lewis (WEHI) for cloning the IL-1 beta vector. This work was supported by National Health and Medical Research (Canberra, Australia) Project grants (1051210, 1101405), fellowships (JEV (1052598); LL (1035502); DLV (1020136)) and Program Grants (461221), and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS (361646). We thank R Crawley for animal care; S Monard and staff for cell sorting; M Hardy for assistance with ELISpots; L Whitehead for assistance with image acquisition.