Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Catherine E Winbanks; Kate T Murphy; Bianca C Bernardo; Hongwei Qian; Yingying Liu; Patricio V Sepulveda; Claudia Beyer; Adam Hagg; Rachel E Thomson; Justin L Chen; Kelly L Walton; Kate L Loveland; Julie R McMullen; Buel D Rodgers; Craig A Harrison; Gordon S Lynch; Paul Gregorevic

Journal article

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Catherine E Winbanks, Kate T Murphy, Bianca C Bernardo, Hongwei Qian, Yingying Liu, Patricio V Sepulveda, Claudia Beyer, Adam Hagg, Rachel E Thomson, Justin L Chen, Kelly L Walton, Kate L Loveland, Julie R McMullen, Buel D Rodgers, Craig A Harrison, Gordon S Lynch, Paul Gregorevic

Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2016

DOI: 10.1126/scitranslmed.aac4976

University of Melbourne Researchers

Gordon Lynch Author Anatomy and Neuroscience

Kate Murphy Author Anatomy and Neuroscience

Rachel Thomson Author Anatomy and Neuroscience

Hongwei Qian Author Anatomy and Neuroscience

Paul Gregorevic Author Anatomy and Neuroscience

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INHIBITING THE RENIN-ANGIOTENSIN SYSTEM TO PREVENT WASTING IN CANCER

Cancer cachexia is a devastating disease characterised by skeletal muscle wasting and weakness. It impairs patient quality of life and accou..

Grants

Awarded by National Health and Medical Research Council (NHMRC, Australia)

Awarded by NHMRC

Awarded by National Science Foundation (NSF, USA)

Funding Acknowledgements

This work was supported by grant funding (526648 and 566820) from the National Health and Medical Research Council (NHMRC, Australia). J.R.M. is supported by a Senior Research Fellowship (1078985) from NHMRC. K.T.M., C.A.H., and P.G. are supported by Career Development Fellowships (1023178, 1013533, and 1046782, respectively) from NHMRC. B.D.R. is supported by the National Science Foundation (NSF, USA; IOS1147275) and the Muscular Dystrophy Association (USA). The Baker IDI Heart and Diabetes Institute is supported in part by the Operational Infrastructure Support Program of the Victorian Government, Australia.