Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica

Cristian A Alvarez Rojas; Jean-Pierre Scheerlinck; Brendan RE Ansell; Ross S Hall; Robin B Gasser; Aaron R Jex

Journal article

Time-Course Study of the Transcriptome of Peripheral Blood Mononuclear Cells (PBMCs) from Sheep Infected with Fasciola hepatica

Cristian A Alvarez Rojas, Jean-Pierre Scheerlinck, Brendan RE Ansell, Ross S Hall, Robin B Gasser, Aaron R Jex

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016

DOI: 10.1371/journal.pone.0159194

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Abstract

Fasciola hepatica is a parasitic trematode that infects a wide range of mammalian hosts, including livestock and humans, in temperate and tropical regions globally. This trematode causes the disease fascioliasis, which consists of an acute phase (≤ 12 weeks) during which juvenile parasites migrate through the host liver tissues, and a chronic phase (> 12 weeks) following the establishment of adult parasites in the liver bile ducts. Few studies have explored the progression of the host response over the course of Fasciola infection in the same animals. In this study, we characterized transcriptomic changes in peripheral blood mononuclear cells (PBMCs) collected from sheep at three time points..

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University of Melbourne Researchers

Jean-Pierre Scheerlinck Author Veterinary Biosciences

Robin Gasser Author Veterinary Biosciences

Aaron Jex Author Veterinary Biosciences

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Grants

Awarded by ARC

Awarded by Victorian Life Sciences Computation Initiative (VLSCI)

Funding Acknowledgements

This work was supported by the Australian Research Council and (ARC) grant number DP110103175 and the National Health and Medical Research Council (NHMRC) of Australia as well as by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0007 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (to RB Gasser).