Journal article

THE PARIETAL-CELL AUTOANTIBODIES RECOGNIZED IN NEONATAL THYMECTOMY-INDUCED MURINE GASTRITIS ARE THE ALPHA-SUBUNIT AND BETA-SUBUNIT OF THE GASTRIC PROTON PUMP

CM JONES, JM CALLAGHAN, PA GLEESON, Y MORI, T MASUDA, BH TOH

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 1991

Abstract

Murine autoimmune gastritis, induced by neonatal thymectomy, bears a striking similarity in pathology to the human autoimmune disease, pernicious anemia. Autoantibodies to parietal cells are found in both murine and human diseases. Monoclonal immunoglobulin G autoantibodies, obtained from neonatally thymectomized mice, have previously been shown to recognize two groups of gastric parietal cell antigens. In the present study, it is shown that two of these monoclonal autoantibodies, designated 1H9 and 2B6, are directed against the alpha subunit and beta subunit, respectively, of the gastric hydrogen-potassium-stimulated adenosine triphosphatase (H+,K(+)-ATPase; proton pump). Monoclonal antibod..

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