Journal article
Quality of life and social functioning during treatment of recent hepatitis C infection: A multi-centre prospective cohort
JS Doyle, J Grebely, T Spelman, M Alavi, GV Matthews, AJ Thompson, GJ Dore, ME Hellard, J Kaldor, P Marks, A Lloyd, P Haber, R French, P White, W Rawlinson, C Day, I Van Beek, G McCaughan, A Madden, K Dolan Show all
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Open access
Abstract
Aim: Despite effective treatment for recent hepatitis C (HCV) infection, side-effects and adherence concerns limit its use among people who inject drugs (PWID). This study evaluated health-related quality of life (HRQoL) and social functioning following infection and during recent HCV treatment. Methods: The Australian Trial of Acute Hepatitis C studied the natural history and treatment of recent HCV infection. HRQoL (SF-12v2) and social functioning (Opiate Treatment Index score) were measured over 48 weeks and their impact on treatment uptake, adherence and virological response were assessed. Results: Of 163 participants, 111 received treatment (HCV n = 74, SVR 55%; HCV/HIV n = 37, SVR 74%)..
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Awarded by National Institutes of Health
Funding Acknowledgements
The ATAHC Study was funded by the National Institutes of Health (grant RO1 DA 15999-01). Roche Pharmaceuticals supplied financial support for pegylated-IFN alfa-2a/ribavirin use in the ATAHC Study. JD, JG, GM, AT, GD, and MH acknowledge fellowship support from the National Health and Medical Research Council. JD, TS and MH acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program (Department of Health, Victoria, Australia) to the Burnet Institute. The Kirby Institute is funded by the Australian Government Department of Health and Ageing. The views expressed in this publication do not necessarily represent the position of the Australian Government. None of the funding sources had any involvement in the conduct, analysis or reporting of the study. Roche Pharmaceuticals had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.