The 'Timing of Androgen-Deprivation therapy in incurable prostate cancer' protocol (TOAD) where are we now? Synopsis of the Victorian Cooperative Oncology Group PR 01-03 and Trans-Tasman Radiation Oncology Group 03.06 clinical trial
Gillian M Duchesne, Henry H Woo
BJU INTERNATIONAL | WILEY | Published : 2014
OBJECTIVE: To outline the development of the 'Timing of Androgen Deprivation' (TOAD) protocol, a collaborative randomised clinical trial under the auspices of the Cancer Council Victoria, the Trans-Tasman Radiation Oncology Group, and the Urological Society of Australia and New Zealand (USANZ), which opened to recruitment in 2004. PATIENTS AND METHODS: The principal hypothesis for the trial was that the early introduction of androgen-deprivation therapy (ADT; experimental arm) at the time when curative therapies are no longer considered an option, would improve overall survival for these patients, whilst maintaining an acceptable quality of life; compared with waiting for disease progression..View full abstract
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This work was funded by the National Health and Medical Research Council (NHMRC), a multistate Cancer Council grant, the Royal Australian and New Zealand College of Radiologists (RANZCR) and an educational grant for data management from Mayne Pharma.