Journal article

Does PET SUV Harmonization Affect PERCIST Response Classification?

Elske Quak, Pierre-Yves Le Roux, Charline Lasnon, Philippe Robin, Michael S Hofman, David Bourhis, Jason Callahan, David S Binns, Cedric Desmonts, Pierre-Yves Salaun, Rodney J Hicks, Nicolas Aide

JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2016

Abstract

Pre- and posttreatment PET comparative scans should ideally be obtained with identical acquisition and processing, but this is often impractical. The degree to which differing protocols affect PERCIST classification is unclear. This study evaluates the consistency of PERCIST classification across different reconstruction algorithms and whether a proprietary software tool can harmonize SUV estimation sufficiently to provide consistent response classification. METHODS: Eighty-six patients with non-small cell lung cancer, colorectal liver metastases, or metastatic melanoma who were scanned for therapy monitoring purposes were prospectively recruited in this multicenter trial. Pre- and posttreat..

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