Journal article
GENETIC-EVIDENCE THAT ZFY IS NOT THE TESTIS-DETERMINING FACTOR
MS PALMER, AH SINCLAIR, P BERTA, NA ELLIS, PN GOODFELLOW, NE ABBAS, M FELLOUS
NATURE | MACMILLAN MAGAZINES LTD | Published : 1989
DOI: 10.1038/342937a0
Abstract
In mammals, the testis determining gene (TDF), present on the Y chromosome, induces the undifferentiated gonads to form testes. The position of TDF on the human Y chromosome has been defined by analysing the genomes of XX males and XY females, generated by abnormal genetic exchange between the X and Y chromosomes in male meiosis. In this way TDF has been localized close to the pseudoautosomal region shared by the sex chromosomes, in the distal Y-specific region. A recently cloned human gene, ZFY, has many features indicating that it is TDF. For example, ZFY encodes a protein with many features of a transcription factor including a domain with multiple 'zinc-finger' motifs. Less consistent wi..
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