Journal article

INTEGRIN EXPRESSION AND DIFFERENTIATION IN TRANSFORMED HUMAN EPIDERMAL-CELLS IS REGULATED BY FIBROBLASTS

P KAUR, WG CARTER

JOURNAL OF CELL SCIENCE | COMPANY OF BIOLOGISTS LTD | Published : 1992

Abstract

Normal human foreskin keratinocytes (HFKs) and transformed HFKs (FEPE1L-8 cells) generated by the introduction of cloned human papillomavirus type 16 sequences were compared for the expression and function of a family of adhesion receptors termed integrins. Initially, cells were examined in conventional monolayer cultures. FEPE1L-8s expressed integrins alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, alpha 6 beta 4 and beta 1 at comparable levels to HFKs. Further, these receptors were fully functional in mediating specific interactions with exogenously supplied ligands. However, FEPE1L-8s exhibited decreased synthesis of a number of extracellular matrix components, including l..

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University of Melbourne Researchers