Journal article

Cytotoxic lymphocyte-mediated immunotherapy

MJ Smyth, MH Kershaw

Australian and New Zealand Journal of Medicine | ADIS PRESS AUSTRALASIA P/L | Published : 1995

Abstract

Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft rejection, antitumour responses, immunoregulation and some autoimmune diseases. The central importance of these cells in each of these immune responses and the therapeutic potential they offer, when effectively targeted, has justified continued interest in their function. Molecular biology has dominated the recent study of cytotoxic lymphocyte function, allowing the characterisation of recognition structures on cytotoxic lymphocytes, the definition of two distinct mechanisms of cytotoxicity and the determination of their relevance in vivo. Biological and genetic experimental approaches which exploit the..

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