Journal article

PROTEIN-KINASE RECOGNITION SEQUENCE MOTIFS

BE KEMP, RB PEARSON

TRENDS IN BIOCHEMICAL SCIENCES | ELSEVIER SCI LTD | Published : 1990

Abstract

Protein kinases play a crucial role in the regulation of many cellular processes. They alter the functions of their target proteins by phosphorylating specific serine, threonine and tyrosine residues. Identification of phosphorylation site sequences and studies with corresponding model peptides have provided clues to how these important enzymes recognize their substrate proteins. This knowledge has made it possible to identify potential sites of phosphorylation in newly sequenced proteins as well as to construct specific model substrates and inhibitors.