NLRC4 inflammasomes in dendritic cells evoke non-cognate effector function by memory CD8 T cells that improve immunity to Salmonella typhimurium

Abstract

Abstract Salmonella enterica is the causative agent of typhoid fever, a condition with considerable global human morbidity and mortality. Although it is well established that interferon-γ (IFN-γ) is critical for the control of Salmonella infections, the cellular source of this protective cytokine and its regulation during Salmonella infection remain unclear. CD4 T cells have been suggested as prime producers of IFN-γ during Salmonella infection. However, in contrast to non-lethal Salmonellosis ensuing in CD4 T cell deficient hosts, mice lacking IFN-γ rapidly succumb to the infection, suggesting that cells other than CD4 T cells contribute to IFN-γ-mediated protection agains..