Journal article
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels
C Bonilla, SJ Lewis, MA Rowlands, TR Gaunt, G Davey Smith, D Gunnell, T Palmer, JL Donovan, FC Hamdy, DE Neal, R Eeles, D Easton, Z Kote-Jarai, AA Al Olama, S Benlloch, K Muir, GG Giles, F Wiklund, H Grönberg, CA Haiman Show all
International Journal of Cancer | WILEY | Published : 2016
DOI: 10.1002/ijc.30206
Abstract
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate cancer and two replication cohorts (N ∼ 900 and ∼9,000), we examined the properties of these SNPS as instrumental variables (IVs) for IGF-I, IGF-II, IGFBP-2 and IGFBP-3. Those confirmed as strong IVs were te..
View full abstractGrants
Awarded by British Columbia Arts Council
Funding Acknowledgements
Grant sponsor: World Cancer Research Fund; Grant number: 2011/419; Grant sponsor: Cancer Research UK; Grant number: C18281/A19169; Grant sponsor: MRC and the University of Bristol; Grant number: G0600705, MC_UU_12013/19 (to Integrative Epidemiology Unit (IEU)); Grant sponsor: Cancer Research UK; Grant number: C18281/A19169 (to Integrative Cancer Epidemiology Programme); Grant sponsor: National Institute for Health Research (NIHR) (to Bristol Biomedical Research Unit in Nutrition, which is a partnership between University Hospitals Bristol NHS Foundation Trust and the University of Bristol); Grant sponsor: National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (to ProtecT study); Grant number: HTA 96/20/99; ISRCTN20141297; Grant sponsor: European Community's Seventh Framework Programme (grant agreement no 223175); Grant number: HEALTH-F2-2009-223175) (COGS) (to PRACTICAL and the iCOGS infrastructure); Grant sponsor: Cancer Research UK; Grant numbers: C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565; Grant sponsor: National Institutes of Health; Grant number: CA128978; Grant sponsor: Post-Cancer GWAS initiative; Grant numbers: 1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 - the GAME-ON initiative; Grant sponsor: Department of Defense; Grant number: W81XWH-10-1-0341; Grant sponsors: Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation and the Ovarian Cancer Research Fund