Journal article

Chronic hepatitis C burden and care cascade in Australia in the era of interferon-based treatment

Behzad Hajarizadeh, Jason Grebely, Hamish McManus, Chris Estes, Homie Razavi, Richard T Gray, Maryam Alavi, Janaki Amin, Skye McGregor, William Sievert, Alexander Thompson, Gregory J Dore

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | WILEY-BLACKWELL | Published : 2017

Abstract

BACKGROUND AND AIM: Interferon-free direct-acting antiviral regimens for hepatitis C virus (HCV) infection have been recently available in Australia, beginning a new era in clinical and public health management of HCV infection. This study provided updated estimates of the HCV infection care cascade and burden in Australia as a reliable platform for assessing the future impact of interferon-free therapies. METHODS: A modeling approach was applied to estimate the number of individuals living with chronic HCV infection and with various liver disease stages. Data from national registries of HCV notification and liver transplantation, literature review, and expert consensus informed the model pa..

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Grants

Awarded by NSW Ministry of Health. BH is recipient of the National Health and Medical Research Council of Australia (NHMRC) Early Career Fellowship


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

The Kirby Institute is funded by the Australian Government Department of Health and is affiliated with the Faculty of Medicine, UNSW Australia. The views expressed in this publication do not necessarily represent the position of the Australian Government. This study is a part of the Blood-borne viruses and sexually transmissible infections Research, Strategic Interventions and Evaluation (BRISE) program, funded by the NSW Ministry of Health. BH is recipient of the National Health and Medical Research Council of Australia (NHMRC) Early Career Fellowship (#1112512). J. G is recipient of the NHMRC Career Development Fellowship (#1035383). G. J. D is recipient of the NHMRC Practitioner Fellowship (#1028432). J. G is a consultant/advisor and has received research grants from Abbvie, Bristol Myers Squibb, Gilead Sciences and Merck. G. J. D is a consultant/advisor and has received research grants from Abbvie, Bristol Myers Squibb, Gilead, Merck, Janssen, and Roche.