The Import of Proteins into the Mitochondrion of Toxoplasma gondii
Giel G van Dooren, Lee M Yeoh, Boris Striepen, Geoffrey I McFadden
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2016
Outside of well characterized model eukaryotes, relatively little is known about the translocons that transport proteins across the two membranes that surround the mitochondrion. Apicomplexans are a phylum of intracellular parasites that cause major diseases in humans and animals and are evolutionarily distant from model eukaryotes such as yeast. Apicomplexans harbor a mitochondrion that is essential for parasite survival and is a validated drug target. Here, we demonstrate that the apicomplexan Toxoplasma gondii harbors homologues of proteins from all the major mitochondrial protein translocons present in yeast, suggesting these arose early in eukaryotic evolution. We demonstrate that a T. ..View full abstract
Awarded by Australian Research Council
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by Discovery Grant DP110103144 from the Australian Research Council (to G. v. D.), a National Health and Medical Research Program Grant (to G. I. M.), and Grant RO1AI 64671 from the National Institutes of Health (to B. S.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.