Journal article
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis
F Souza-Fonseca-Guimaraes, Y Krasnova, T Putoczki, K Miles, KP Macdonald, L Town, W Shi, GC Gobe, L McDade, LA Mielke, H Tye, SL Masters, GT Belz, ND Huntington, G Radford-Smith, MJ Smyth
Cell Death and Disease | NATURE PUBLISHING GROUP | Published : 2016
Abstract
Inflammatory bowel disease (IBD) is an immunoregulatory disorder, associated with a chronic and inappropriate mucosal immune response to commensal bacteria, underlying disease states such as ulcerative colitis (UC) and Crohn’s disease (CD) in humans. Granzyme M (GrzM) is a serine protease expressed by cytotoxic lymphocytes, in particular natural killer (NK) cells. Granzymes are thought to be involved in triggering cell death in eukaryotic target cells; however, some evidence supports their role in inflammation. The role of GrzM in the innate immune response to mucosal inflammation has never been examined. Here, we discover that patients with UC, unlike patients with CD, display high levels o..
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Funding Acknowledgements
We thank Clay Winterford, Nigel Waterhouse, Lisa Simms, Lutz Krause, Martha Zakrzewski, Motti Gerlic, Simon Keely, Stephen A Wilcox, and Tobias Bald for providing reagents, discussion, comments, and advice in this project, and Cathy Quilici, Eren Loza, Kate Elder, Leesa Wockner, Louise Spencer, Rebecca Delconte, and Tam Nguyen for technical support. MJS was supported by an NHMRC Senior Principal Research Fellowship. FSFG was supported by an NHMRC Early Career Fellowship and National Breast Cancer Foundation (NBCF) Fellowship, and Cancer Cure Australia Priority-driven Young Investigator Project Grant.