Journal article

Operator variability in scan positioning is a major component of HR-pQCT precision error and is reduced by standardized training

S Bonaretti, N Vilayphiou, CM Chan, A Yu, K Nishiyama, D Liu, S Boutroy, A Ghasem-Zadeh, SK Boyd, R Chapurlat, H McKay, E Shane, ML Bouxsein, DM Black, S Majumdar, ES Orwoll, TF Lang, S Khosla, AJ Burghardt

OSTEOPOROSIS INTERNATIONAL | SPRINGER LONDON LTD | Published : 2017

Abstract

In this study, we determined that operator positioning precision contributes significant measurement error in high-resolution peripheral quantitative computed tomography (HR-pQCT). Moreover, we developed software to quantify intra- and inter-operator variability and demonstrated that standard positioning training (now available as a web-based application) can significantly reduce inter-operator variability. INTRODUCTION: HR-pQCT is increasingly used to assess bone quality, fracture risk, and anti-fracture interventions. The contribution of the operator has not been adequately accounted in measurement precision. Operators acquire a 2D projection ("scout view image") and define the region to b..

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University of Melbourne Researchers

Grants

Awarded by NIH/NIAMS


Awarded by NIH Roadmap for Medical Research


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

This study was funded by the NIH/NIAMS R01 AR060700 and by The Osteoporotic Fractures in Men (MrOS) study, which is supported by the National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.