Journal article

Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology

Laura S van Velzen, Lianne Schmaal, Rick Jansen, Yuri Milaneschi, Esther M Opmeer, Bernet M Elzinga, Nic JA van der Wee, Dick J Veltman, Brenda WJH Penninx

Social Cognitive and Affective Neuroscience | OXFORD UNIV PRESS | Published : 2016


Childhood maltreatment (CM) has been associated with altered brain morphology, which may partly be due to a direct impact on neural growth, e.g. through the brain-derived neurotrophic factor (BDNF) pathway. Findings on CM, BDNF and brain volume are inconsistent and have never accounted for the entire BDNF pathway. We examined the effects of CM, BDNF (genotype, gene expression and protein level) and their interactions on hippocampus, amygdala and anterior cingulate cortex (ACC) morphology. Data were collected from patients with depression and/or an anxiety disorder and healthy subjects within the Netherlands Study of Depression and Anxiety (NESDA) (N = 289). CM was assessed using the Childhoo..

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Awarded by Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw)

Awarded by NWO VICI grant

Awarded by Netherlands Brain Foundation

Funding Acknowledgements

The infrastructure for the NESDA study is funded through the Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw, grant number 10-000-1002) and is supported by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of Health Care (IQ Healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos). LvV, LS and BWJHP are supported by NWO VICI grant (number 91811602). LS is supported by The Netherlands Brain Foundation Grant number F2014(1)-24.