Restoration of intestinal function in an MPTP model of Parkinson's Disease
LJ Ellett, LW Hung, R Munckton, NA Sherratt, J Culvenor, A Grubman, JB Furness, AR White, DI Finkelstein, KJ Barnham, VA Lawson
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2016
Patients with Parkinson's disease often experience non-motor symptoms including constipation, which manifest prior to the onset of debilitating motor signs. Understanding the causes of these non-motor deficits and developing disease modifying therapeutic strategies has the potential to prevent disease progression. Specific neuronal subpopulations were reduced within the myenteric plexus of mice 21 days after intoxication by the intraperitoneal administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and was associated with a reduction in stool frequency, indicative of intestinal dysfunction. Oral administration of the divalent copper complex, Cu(II)(atsm), which has been shown t..View full abstract
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Awarded by National Health & Medical Research Council (NHMRC) of Australia
Supported by funds from the Australian Research Council, the National Health & Medical Research Council (NHMRC) of Australia (Program Grant 628946 to KJB: Senior Research Fellowship APP1002373 to KJB). Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.