Tumor suppressor functions of the Src-like adaptor protein (SLAP) in colorectal cancer cells

Abstract

Abstract Background : The cytoplasmic tyrosine kinase Src is frequently deregulated in colorectal cancer (CRC) and this deregulation is implicated in tumour growth and in the induction of metastasis. How Src is activated in this cancer has not been clearly established. In contrast to Ras, Src activating mutations are rare events, suggesting the existence of alternative mechanisms for the induction of Src oncogenic activity. Here, we addressed whether Src deregulation involves inhibition of its negative regulators, including the Src-Like Adaptor Protein (SLAP). Experimental procedures : SLAP expression was analyzed in colon cancer cells and in microdissected tiss..