Journal article

Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial

Sharon M Moe, Glenn M Chertow, Patrick S Parfrey, Yumi Kubo, Geoffrey A Block, Ricardo Correa-Rotter, Tilman B Drueeke, Charles A Herzog, Gerard M London, Kenneth W Mahaffey, David C Wheeler, Maria Stolina, Bastian Dehmel, William G Goodman, Juergen Floege

CIRCULATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

BACKGROUND: Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. METHODS AND RESULTS: This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidi..

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University of Melbourne Researchers