Journal article
South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study
H Chung The, MA Rabaa, D Pham Thanh, N De Lappe, M Cormican, M Valcanis, BP Howden, S Wangchuk, L Bodhidatta, CJ Mason, T Nguyen Thi Nguyen, D Vu Thuy, CN Thompson, N Phu Huong Lan, P Voong Vinh, T Ha Thanh, P Turner, P Sar, G Thwaites, NR Thomson Show all
Plos Medicine | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Background: Antimicrobial resistance is a major issue in the Shigellae, particularly as a specific multidrug-resistant (MDR) lineage of Shigella sonnei (lineage III) is becoming globally dominant. Ciprofloxacin is a recommended treatment for Shigella infections. However, ciprofloxacin-resistant S. sonnei are being increasingly isolated in Asia and sporadically reported on other continents. We hypothesized that Asia is a primary hub for the recent international spread of ciprofloxacin-resistant S. sonnei. Methods and Findings: We performed whole-genome sequencing on a collection of 60 contemporaneous ciprofloxacin-resistant S. sonnei isolated in four countries within Asia (Vietnam, n = 11; Bh..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). NRT is supported by the Wellcome Trust grant #098051 to Wellcome Trust Sanger Institute. KEH is supported by fellowship #1061409 from the NHMRC of Australia. BPH is supported by fellowship #1023526 from the NHMRC of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.