Journal article

South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study

Chung The Hao, Maia A Rabaa, Pham Thanh Duy, Niall De Lappe, Martin Cormican, Mary Valcanis, Benjamin P Howden, Sonam Wangchuk, Ladaporn Bodhidatta, Carl J Mason, Nguyen Thi Nguyen To, Vu Thuy Duong, Corinne N Thompson, Phu Huong Lan Nguyen, Voong Vinh Phat, Ha Thanh Tuyen, Paul Turner, Poda Sar, Guy Thwaites, Nicholas R Thomson Show all

PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2016

Abstract

BACKGROUND: Antimicrobial resistance is a major issue in the Shigellae, particularly as a specific multidrug-resistant (MDR) lineage of Shigella sonnei (lineage III) is becoming globally dominant. Ciprofloxacin is a recommended treatment for Shigella infections. However, ciprofloxacin-resistant S. sonnei are being increasingly isolated in Asia and sporadically reported on other continents. We hypothesized that Asia is a primary hub for the recent international spread of ciprofloxacin-resistant S. sonnei. METHODS AND FINDINGS: We performed whole-genome sequencing on a collection of 60 contemporaneous ciprofloxacin-resistant S. sonnei isolated in four countries within Asia (Vietnam, n = 11; Bh..

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Grants

Awarded by Wellcome Trust


Awarded by Royal Society


Awarded by NHMRC of Australia


Funding Acknowledgements

SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). NRT is supported by the Wellcome Trust grant #098051 to Wellcome Trust Sanger Institute. KEH is supported by fellowship #1061409 from the NHMRC of Australia. BPH is supported by fellowship #1023526 from the NHMRC of Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.