Journal article

The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis

Niloufar Torkamani, Nicholas Rufaut, Leslie Jones, Rodney Sinclair



Proximally, the arrector pili muscle (APM) attaches to the follicular stem cell niche in the bulge, but its distal properties are comparatively unclear. In this work, a novel method employing an F-actin probe, phalloidin, was employed to visualize the APM anatomy. Phalloidin staining of the APM was validated by comparison with conventional antibodies/stains and by generating three-dimensional reconstructions. The proximal attachment of the APM to the bulge in 8 patients with androgenic alopecia was studied using Masson's trichrome stain. Phalloidin visualized extensive branching of the APM. The distal end of the human APM exhibits a unique "C"-shaped structure connecting to the dermal-epider..

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Funding Acknowledgements

This study was funded by a University of Melbourne International Research Scholarship, a John Hayden Scholarship, and an Alwyn Stewart Memorial Trust Fund Faculty of Medicine Research Scholarship (University of Melbourne).