Journal article

The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis

Niloufar Torkamani, Nicholas Rufaut, Leslie Jones, Rodney Sinclair

ANATOMICAL SCIENCE INTERNATIONAL | SPRINGER | Published : 2017

Abstract

Proximally, the arrector pili muscle (APM) attaches to the follicular stem cell niche in the bulge, but its distal properties are comparatively unclear. In this work, a novel method employing an F-actin probe, phalloidin, was employed to visualize the APM anatomy. Phalloidin staining of the APM was validated by comparison with conventional antibodies/stains and by generating three-dimensional reconstructions. The proximal attachment of the APM to the bulge in 8 patients with androgenic alopecia was studied using Masson's trichrome stain. Phalloidin visualized extensive branching of the APM. The distal end of the human APM exhibits a unique "C"-shaped structure connecting to the dermal-epider..

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Grants

Funding Acknowledgements

This study was funded by a University of Melbourne International Research Scholarship, a John Hayden Scholarship, and an Alwyn Stewart Memorial Trust Fund Faculty of Medicine Research Scholarship (University of Melbourne).