Journal article

Breast Milk Feeding, Brain Development, and Neurocognitive Outcomes: A 7-Year Longitudinal Study in Infants Born at Less Than 30 Weeks' Gestation

Mandy B Belfort, Peter J Anderson, Victoria A Nowak, Katherine J Lee, Charlotte Molesworth, Deanne K Thompson, Lex W Doyle, Terrie E Inder

The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2016

Abstract

OBJECTIVES: To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants STUDY DESIGN: We studied 180 infants born at <30 weeks' gestation or 50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression. RESULTS: A greater number of days on which infants received >50% breast milk wa..

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Grants

Awarded by Centre of Clinical Research Excellence


Awarded by Centre of Research Excellence in Newborn Medicine


Awarded by National Institutes of Health


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Funding Acknowledgements

Funded by Australia's National Health & Medical Research Council; Centre of Clinical Research Excellence (546519 [to L.D. and P.A.]); Centre of Research Excellence in Newborn Medicine (1060733 [to L.D., P.A., and D.T.]); (237117 [to L.D.]); (491209 [to P. A.]); Senior Research Fellowship (1081288 [to P. A.]); Early Career Fellowships (1012236 [to D.T.] and 1053787 [to J.C.]); Career Development Fellowships (1085754 [to D.T.] and 1053609 [to K.L.]); National Institutes of Health (HD058056); United Cerebral Palsy Foundation (US); Leila Y. Mathers Charitable Foundation (US); the Brown Foundation (US); the Victorian Government's Operational Infrastructure Support Program; and The Royal Children's Hospital Foundation. V.N. was supported by the Cambridge Commonwealth Travelling Bursary (St John's College, Cambridge); Mary Euphrasia Mosley and Sir Bartle Frere Fund; Lord Mayor's 800th Anniversary Awards Trust; Nichol Young Foundation; and the Worts Travelling Scholars' Award. T.I. served on the Editorial Board of The Journal of Pediatrics (2007-2015). The other authors declare no conflicts of interest.