Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats
Wendy TK Ip, Andrew McAlindon, Sarah E Miller, James R Bell, Claire L Curl, Catherine E Huggins, Kimberley M Mellor, Antonia JA Raaijmakers, Laura A Bienvenu, Peter L McLennan, Salvatore Pepe, Lea MD Delbridge
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2016
A definitive understanding of the role of dietary lipids in determining cardioprotection (or cardiodetriment) has been elusive. Randomized trial findings have been variable and sex specificity of dietary interventions has not been determined. In this investigation the sex-selective cardiac functional effects of three diets enriched by omega-3 or omega-6 polyunsaturated fatty acids (PUFA) or enriched to an equivalent extent in saturated fatty acid components were examined in rats after an 8-wk treatment period. In females the myocardial membrane omega-6:omega-3 PUFA ratio was twofold higher than males in the omega-6 diet replacement group. In diets specified to be high in omega-3 PUFA or in s..View full abstract
Project funding support was received from the National Health and Research Council of Australia (to L. M. Delbridge, S. Pepe, and P. L. McLennan).