Activation of TRIF-dependent and independent immune responses by neisserial heat shock protein complex vaccines
Garrett Z Ng, Jia-Xi Han, Camilo A Colaco, Philip Sutton
HUMAN VACCINES & IMMUNOTHERAPEUTICS | TAYLOR & FRANCIS INC | Published : 2016
ASBTRACT Heat shock protein Complex (HspC) vaccines are composed of Hsp purified from pathogenic bacteria along with their chaperoned protein cargo. Mouse studies have shown that HspC vaccines can induce a strong immune response against pathogenic bacteria without addition of an exogenous adjuvant. These vaccines are now entering clinical trials. It was predicted, but not previously tested, that HspC vaccines induce an immune response due to the activation of Toll-Like Receptors (TLR) by their component Hsp. Recently we tested this supposition and found that while this held true for the cellular response to neisserial HspC vaccines, strong antigen-specific antibody responses were surprisingl..View full abstract
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Awarded by Australian Research Council
This work was supported by the Victorian Government's Operational Infrastructure Support Program, by ARC Linkage Grant LP120100226 from the Australian Research Council and by ImmunoBiology Limited.