Two distinct symptom-based phenotypes of depression in epilepsy yield specific clinical and etiological insights
Genevieve Rayner, Graeme D Jackson, Sarah J Wilson
EPILEPSY & BEHAVIOR | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016
Depression is common but underdiagnosed in epilepsy. A quarter of patients meet criteria for a depressive disorder, yet few receive active treatment. We hypothesize that the presentation of depression is less recognizable in epilepsy because the symptoms are heterogeneous and often incorrectly attributed to the secondary effects of seizures or medication. Extending the ILAE's new phenomenological approach to classification of the epilepsies to include psychiatric comorbidity, we use data-driven profiling of the symptoms of depression to perform a preliminary investigation of whether there is a distinctive symptom-based phenotype of depression in epilepsy that could facilitate its recognition..View full abstract
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Awarded by NHMRC
The work of G.J. is supported by an NHMRC Program Grant (#400121), an NHMRC Practitioner Fellowship (#527800), and a Victorian Government Operational Infrastructure Support Grant. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.