Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes: A Structural Model
Keith J Cross, N Laila Huq, Eric C Reynolds
BIOCHEMISTRY | AMER CHEMICAL SOC | Published : 2016
Tryptic digestion of the calcium-sensitive caseins yields casein phosphopeptides (CPP) that contain clusters of phosphorylated seryl residues. The CPP stabilize calcium and phosphate ions through the formation of complexes. The calcium phosphate in these complexes is biologically available for intestinal absorption and remineralization of subsurface lesions in tooth enamel. We have studied the structure of the complexes formed by the CPP with calcium phosphate using a variety of nuclear magnetic resonance (NMR) techniques. Translational diffusion measurements indicated that the β-CN(1-25)-ACP nanocomplex has a hydrodynamic radius of 1.526 ± 0.044 nm at pH 6.0, which increases to 1.923 ± 0.08..View full abstract
Supported by the Australian Government, Department of Industry, Innovation and Science.