Journal article

Synthesis of Oxorhenium(V) and Oxotechnetium(V) Complexes That Bind to Amyloid-beta Plaques

David J Hayne, Jonathan M White, Catriona A McLean, Victor L Villemagne, Kevin J Barnham, Paul S Donnelly



Alzheimer's disease is characterized by the presence of amyloid plaques in the brain. The primary constituents of the plaques are aggregated forms of the amyloid-β (Aβ) peptide. With the goal of preparing technetium-99(m) complexes that bind to Aβ plaques with the potential to be diagnostic imaging agents for Alzheimer's disease, new tetradentate ligands capable of forming neutral and lipophilic complexes with oxotechentium(V) and oxorhenium(V) were prepared. Nonradioactive isotopes of technetium are not available so rhenium was used as a surrogate for exploratory chemistry. Two planar tetradentate N3O ligands were prepared that form charge-neutral complexes with oxorhenium(v) as well as a l..

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Funding Acknowledgements

Financial support from the Australian Research Council (ARC) is acknowledged. P.S.D. is an ARC Future Fellow. V.L.V. is an NHMRC Senior Research Fellow. The Victorian Brain Bank Network is acknowledged for the provision of human tissue. We acknowledge the generous support of Prof. Andrew M. Scott, A/Prof. Henri Tochon-Danguy, A/Prof. Uwe Ackermann, Dr. FT Lee, Nick Alexopoulos, and David Thomas of the Austin Hospital, Heidelberg, Victoria, Australia, for providing access to <SUP>99m</SUP>Tc and radiochemistry facilities. Dr. Asif Noor, Lachlan E. McInnes, and Scott P. Fletcher (all University of Melbourne) are thanked for help with A beta<INF>1-42</INF> synthesis and binding measurements.