Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis
Brendan RE Ansell, Malcolm J McConville, Louise Baker, Pasi K Korhonen, Samantha J Emery, Staffan G Svard, Robin B Gasser, Aaron R Jex
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2016
Understanding how parasites respond to stress can help to identify essential biological processes. Giardia duodenalis is a parasitic protist that infects the human gastrointestinal tract and causes 200 to 300 million cases of diarrhea annually. Metronidazole, a major antigiardial drug, is thought to cause oxidative damage within the infective trophozoite form. However, treatment efficacy is suboptimal, due partly to metronidazole-resistant infections. To elucidate conserved and stress-specific responses, we calibrated sublethal metronidazole, hydrogen peroxide, and thermal stresses to exert approximately equal pressure on trophozoite growth and compared transcriptional responses after 24 h o..View full abstract
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Awarded by Australian Research Council (ARC)
This work, including the efforts of Malcolm J. McConville, was funded by Australian Research Council (ARC) (LP120200122). This work, including the efforts of Aaron R. Jex, was funded by Australian Research Council (ARC) (LP120200122).