Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling
Keiko Hojo, Mohammed Akhter Hossain, Julien Tailhades, Fazel Shabanpoor, Lilian LL Wong, Emma EK Ong-Palsson, Hanna E Kastman, Sherie Ma, Andrew L Gundlach, K Johan Rosengren, John D Wade, Ross AD Bathgate
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2016
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Awarded by NHMRC (Australia)
This research was partly funded by NHMRC (Australia) project grants (508995) to J.D.W. and R.A.D.B. and (1065481 and 1066369) to R.A.D.B., K.J.R, and A.L.G. This research was also funded by The Naito Foundation (Japan) Subsidy for Female Researchers to K.H. We are grateful to Tania Ferraro and Sharon Layfield for assistance with cell-based assays and to Feng Lin for amino acid analysis. We thank Prof. Andrea Robinson and Dr. Alessia Belgi (Monash University, Australia) for assistance with the RCM reactions. During these studies, M.A.H. was the recipient of a Florey Foundation Fellowship. A.L.G. and R.A.D.B. are NHMRC Senior Research Fellows, and J.D.W. is an NHMRC Principal Research Fellow. K.J.R is an Australian Research Council Future Fellow. Studies at the Florey were supported by the Victorian Government's Operational Infrastructure Support Program.