Journal article

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern

The Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2016

DOI: 10.1084/jem.20160312

University of Melbourne Researchers

Reema Jain Author Medical Biology (W.E.H.I.)

Daniel Gray Author Medical Biology (W.E.H.I.)

Haiyin Liu Author Biochemistry and Molecular Biology

Jose Villadangos Author Biochemistry and Molecular Biology

Justine Mintern Author Biochemistry and Molecular Biology

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia program

Awarded by NHMRC project

Awarded by Human Frontier Science Program

Awarded by Australian Research Council Discovery Project

Funding Acknowledgements

This research was supported by National Health and Medical Research Council (NHMRC) of Australia program grants (1016629 and 1071916), NHMRC project grants (1078763, 1049724, and 1058193), a Human Frontier Science Program grant (RGP0064), and an Australian Research Council Discovery Project grant (DP110101383). H. Liu and J. Guan were supported by University of Melbourne International Research scholarships. N.L. La Gruta is a Sylvia and Charles Viertel Senior Medical Research Fellow, D.H. Gray is an NHMRC Career Development Fellow (Level 2, 1090236), and J.A. Villadangos is an NHMRC Principal Research Fellow (1058193). This work was made possible through Victorian State Government Operational Infrastructure support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.

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Keywords

Life Sciences & Biomedicine

Membrane Glycoproteins

Antigen Presentation

Medicine, Research & Experimental

Cd4-Positive T-Lymphocytes

Dendritic Cells

Mice, Inbred C57bl

Ubiquitin-Protein Ligases

Science & Technology

Histocompatibility Antigens Class Ii

Epithelial Cells

Immunoglobulins

Research & Experimental Medicine