Journal article
Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials
KR Lees, J Emberson, L Blackwell, E Bluhmki, SM Davis, GA Donnan, JC Grotta, M Kaste, R Von Kummer, MG Lansberg, RI Lindley, P Lyden, GD Murray, PAG Sandercock, D Toni, K Toyoda, JM Wardlaw, WN Whiteley, C Baigent, W Hacke Show all
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
Abstract
Background - Thrombolytic therapy with intravenous alteplase within 4.5 hours of ischemic stroke onset increases the overall likelihood of an excellent outcome (no, or nondisabling, symptoms). Any improvement in functional outcome distribution has value, and herein we provide an assessment of the effect of alteplase on the distribution of the functional level by treatment delay, age, and stroke severity. Methods - Prespecified pooled analysis of 6756 patients from 9 randomized trials comparing alteplase versus placebo/open control. Ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant interaction term(s). Re..
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Awarded by Medical Research Council
Funding Acknowledgements
This collaboration is coordinated by the Clinical Trial Service Unit and Epidemiological Studies Unit at the University of Oxford, United Kingdom. The Unit receives core funding from the UK Medical Research Council and the British Heart Foundation. This work also received support from the University of Glasgow and University of Edinburgh.