Journal article

Randomized Trial of Thymectomy in Myasthenia Gravis

GI Wolfe, HJ Kaminski, IB Aban, G Minisman, H-C Kuo, A Marx, P Strobel, C Mazia, J Oger, JG Cea, JM Heckmann, A Evoli, W Nix, E Ciafaloni, G Antonini, R Witoonpanich, JO King, SR Beydoun, CH Chalk, AC Barboi Show all

New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2016

Abstract

BACKGROUND: Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone. METHODS: We compared extended transsternal thymectomy plus alternate-day prednisone with alternate-day prednisone alone. Patients 18 to 65 years of age who had generalized nonthymomatous myasthenia gravis with a disease duration of less than 5 years were included if they had Myasthenia Gravis Foundation of America clinical class II to IV disease (on a scale from I to V, with higher classes indicating more severe disease) and elevated circulating concentrati..

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