Journal article

THE EPIDERMAL GROWTH-FACTOR RECEPTOR AS A PROGNOSTIC MARKER - RESULTS OF 370 PATIENTS AND REVIEW OF 3009 PATIENTS

SB FOX, K SMITH, J HOLLYER, M GREENALL, D HASTRICH, AL HARRIS

BREAST CANCER RESEARCH AND TREATMENT | KLUWER ACADEMIC PUBL | Published : 1994

Abstract

Epidermal growth factor receptor (EGFR) and estrogen receptor (ER) were assayed by ligand binding in tumors from 370 patients with primary breast carcinoma with a median follow up of 18 months. Forty seven percent (175/370) and 57% (210/370) of tumors had > 20 fmol/mg and > 10 fmol/mg of EGFR and ER respectively. There was a highly significant inverse relationship between EGFR and ER (p = 0.0032). There was also a significant association between EGFR and patient age (p = 0.0006) but not correlation between EGFR and lymph node status, tumor grade, or tumor size (p = 0.104, p = 0.198, and p = 0.085 respectively). In a univariate analysis of all patients, EGFR expression was not associated with..

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