Journal article

TUMOR ANGIOGENESIS IN NODE-NEGATIVE BREAST CARCINOMAS - RELATIONSHIP WITH EPIDERMAL GROWTH-FACTOR RECEPTOR, ESTROGEN-RECEPTOR, AND SURVIVAL

SB FOX, RD LEEK, K SMITH, J HOLLYER, M GREENALL, AL HARRIS

BREAST CANCER RESEARCH AND TREATMENT | KLUWER ACADEMIC PUBL | Published : 1994

Abstract

Angiogenesis is essential for tumor growth and metastases. Studies in breast carcinomas suggest that microvessel quantitation as a measure of angiogenesis might be one of the most powerful prognostic tools available. Node negative breast cancer is a particular group for which better prognostic markers would be helpful. We therefore measured microvessel density in a series of well characterised node negative breast carcinomas to evaluate angiogenesis as a prognostic marker and assess its relationship to epidermal growth factor receptor (EGFR) and estrogen receptor (ER), which have previously been reported to be of value. 109 patients with a mean age of 55 years and a median follow-up of 25 mo..

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