Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.
Khoon Lin Ling, Sarah E Pratap, Gaynor J Bates, Baljit Singh, Neil J Mortensen, Bruce D George, Bryan F Warren, Juan Piris, Giovanna Roncador, Stephen B Fox, Alison H Banham, Vincenzo Cerundolo
Cancer Immunology Research | Published : 2007
Recent results have shown a correlation between survival and frequency of tumour infiltrating T lymphocytes in colorectal cancer patients. However, it remains unclear whether the frequency of regulatory T cells is higher in colorectal cancer as compared to normal colon. To address this question we analysed the frequency and function of regulatory T cells in the peripheral blood and tumour infiltrating lymphocytes of colorectal cancer patients. The proportion of regulatory T cells in the peripheral blood of colorectal cancer patients (mean 8%) was significantly higher than that in normal controls (mean 2.2%). There were significantly more regulatory T cells in tumour infiltrating lymphocytes ..View full abstract