Journal article
Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: A nested case-control study
EJ Rebecca, A Lukanova, L Dossus, S Becker, S Rinaldi, A Tjønneland, A Olsen, K Overvad, S Mesrine, P Engel, F Clavel-Chapelon, J Chang-Claude, A Vrieling, H Boeing, M Schütze, A Trichopoulou, P Lagiou, D Trichopoulos, D Palli, V Krogh Show all
Cancer Prevention Research | AMER ASSOC CANCER RESEARCH | Published : 2011
Abstract
Prediagnostic endogenous sex steroid hormone levels have well established associations with overall risk of breast cancer. While evidence toward the existence of distinct subtypes of breast cancer accumulates, few studies have investigated the associations of sex steroid hormone levels with risk of hormone receptor [estrogen receptor (ER) and/or progesterone receptor (PR)] defined breast cancer. In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood ..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
This study was (partly) funded by a grant from the German Research Foundation, Graduiertenkolleg 793: Epidemiology of communicable and chronic noncommunicable diseases and their interrelationships. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue contre le Cancer, Mutuelle Generale de l' Education Nationale, Institut National de la Sante et de la Recherche Medicale (France); Deutsche Krebshilfe, Deutsches Krebs-forschungszentrum and Federal Ministry of Education and Research (Germany); the Stavros Niarchos Foundation, the Hellenic Health Foundation and the Hellenic Ministry of Health. (Greece); Italian Association for Research on Cancer (AIRC) and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health. (Norway); Health Research Fund (FIS), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020; Spain); Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skane and Vasterbotten (Sweden); Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, and Wellcome Trust (United Kingdom).