Journal article
Association between osteocalcin and cognitive performance in healthy older adults
S Bradburn, JS Mcphee, L Bagley, S Sipila, L Stenroth, MV Narici, M Pääsuke, H Gapeyeva, G Osborne, L Sassano, CGM Meskers, AB Maier, JY Hogrel, Y Barnouin, G Butler-Browne, C Murgatroyd
Age and Ageing | OXFORD UNIV PRESS | Published : 2016
Open access
Abstract
Introduction: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults. Methods: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dualenergy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 2..
View full abstractGrants
Awarded by European Commission
Funding Acknowledgements
The MyoAge project was supported by a research grant from the European Union FP7 (223576).