Journal article
Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells
S Weilner, E Schraml, M Wieser, P Messner, K Schneider, K Wassermann, L Micutkova, K Fortschegger, AB Maier, R Westendorp, H Resch, S Wolbank, H Redl, P Jansen-Dürr, P Pietschmann, R Grillari-Voglauer, J Grillari
Aging Cell | WILEY | Published : 2016
DOI: 10.1111/acel.12484
Abstract
© 2016 The Anatomical Society and John Wiley & Sons Ltd.Damage to cells and tissues is one of the driving forces of aging and age-related diseases. Various repair systems are in place to counteract this functional decline. In particular, the property of adult stem cells to self-renew and differentiate is essential for tissue homeostasis and regeneration. However, their functionality declines with age (Rando, 2006). One organ that is notably affected by the reduced differentiation capacity of stem cells with age is the skeleton. Here, we found that circulating microvesicles impact on the osteogenic differentiation capacity of mesenchymal stem cells in a donor-age-dependent way. While searchin..
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Awarded by FWF Project
Awarded by GEN-AU Project
Awarded by Austrian Science Fund (FWF)
Funding Acknowledgements
This work has been supported by FWF Project P24498, the GEN-AU Project 820982 'Non-coding RNAs', FP7 project FRAILOMIC, as well as grants by the Herzfelder'sche Familienstiftung. The financial support by the Austrian Federal Ministry of Economy, Family and Youth and the National Foundation for Research, Technology and Development is gratefully acknowledged as well as financial support by Chanel Research and Technology.