Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth
P Murthi, DE van Zanten, JJH Eijsink, AJ Borg, JL Stevenson, B Kalionis, AK Chui, JM Said, SP Brennecke, JJHM Emrich
PLACENTA | W B SAUNDERS CO LTD | Published : 2016
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnancies are often associated with histological evidence of placental vascular thrombosis. The proteoglycans are important components and regulators of vascular homeostasis. Previous studies from our laboratory highlighted mRNA and protein expression differences in placental proteoglycan decorin (DCN), within a clinically well-characterised cohort of third-trimester idiopathic FGR compared with gestation-matched uncomplicated control pregnancies. We also showed that decorin contributes to abnormal angiogenesis and increased thrombin generation in vitro. These observations suggest that DCN gene expr..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Sources of funding: this work was supported by a National Health and Medical Research Council (NH&MRC) Project Grant, Australia (Application: 1004952 and 75124).