Journal article

Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth

P Murthi, DE van Zanten, JJH Eijsink, AJ Borg, JL Stevenson, B Kalionis, AK Chui, JM Said, SP Brennecke, JJHM Emrich

PLACENTA | W B SAUNDERS CO LTD | Published : 2016

Abstract

Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnancies are often associated with histological evidence of placental vascular thrombosis. The proteoglycans are important components and regulators of vascular homeostasis. Previous studies from our laboratory highlighted mRNA and protein expression differences in placental proteoglycan decorin (DCN), within a clinically well-characterised cohort of third-trimester idiopathic FGR compared with gestation-matched uncomplicated control pregnancies. We also showed that decorin contributes to abnormal angiogenesis and increased thrombin generation in vitro. These observations suggest that DCN gene expr..

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