The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser
Immunity | CELL PRESS | Published : 2016
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank J. Lochland and C. Hall for genotyping, J.G. Zhang for FASL, M. Yang for technical assistance, and S. Hedrick (UC) for Casp8<SUP>-/-</SUP> mice. S.A.-D. was supported by a Spanish Ministry of Education Postdoctoral Fellowship. M.C.T. was supported by a Victorian International Research Scholarship. This work was funded by grants and fellowships from the National Health and Medical Research Council (NHMRC) (1016647, 1058344, 1079250, 1047672, 1025594, 1057905, and 1046984), the Australian Cancer Research Fund, the U.S. NIH, and the American Lebanese Syrian Associated Charities. This work made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS (361646).