The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz; Christopher P Dillon; Najoua Lalaoui; Maria C Tanzer; Diego A Rodriguez; Ann Lin; Marion Lebois; Razq Hakem; Emma C Josefsson; Lorraine A O'Reilly; John Silke; Warren S Alexander; Douglas R Green; Andreas Strasser

Journal article

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Immunity | CELL PRESS | Published : 2016

DOI: 10.1016/j.immuni.2016.07.016

University of Melbourne Researchers

Najoua Lalaoui Author Medical Biology (W.E.H.I.)

Emma Josefsson Author Medical Biology (W.E.H.I.)

Silvia Alvarez-Diaz Author Medical Biology (W.E.H.I.)

John Silke Author Medical Biology (W.E.H.I.)

Andreas Strasser Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

We thank J. Lochland and C. Hall for genotyping, J.G. Zhang for FASL, M. Yang for technical assistance, and S. Hedrick (UC) for Casp8<SUP>-/-</SUP> mice. S.A.-D. was supported by a Spanish Ministry of Education Postdoctoral Fellowship. M.C.T. was supported by a Victorian International Research Scholarship. This work was funded by grants and fellowships from the National Health and Medical Research Council (NHMRC) (1016647, 1058344, 1079250, 1047672, 1025594, 1057905, and 1046984), the Australian Cancer Research Fund, the U.S. NIH, and the American Lebanese Syrian Associated Charities. This work made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS (361646).