Journal article

Evidence of Gene-Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

Tao Wu, Holger Schwender, Ingo Ruczinski, Jeffrey C Murray, Mary L Marazita, Ronald G Munger, Jacqueline B Hetmanski, Margaret M Parker, Ping Wang, Tanda Murray, Margaret Taub, Shuai Li, Richard J Redett, M Daniele Fallin, Kung Yee Liang, Yah Huei Wu-Chou, Samuel S Chong, Vincent Yeow, Xiaoqian Ye, Hong Wang Show all

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Grants

Awarded by National Institute for Dental and Craniofacial Research


Awarded by International Collaborative Genetics Research Training Program (ICGRTP), NIH from National Natural Science of China



Awarded by FOGARTY INTERNATIONAL CENTER


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH


Awarded by NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Funding Acknowledgements

Funding to support data collection, genotyping and analysis came from several sources, some to individual investigators (R01-DE-014581, R01-DE-016148, P50-DE-016215, R21-DE-016930, R01-DE-09886, R37-DE-08559, U01-DE-020057, R37-DE-0-8559, U01-DE-020057, R01-DE-012472, R01-DE-0106877) and some to the cleft consortium itself (U01-DE-018993). This project was part of the Gene, Environment Association Studies (GENEVA) Consortium funded by the National Human Genome Research Institute (NHGRI) to enhance communication and collaboration among researchers conducting genome-wide studies of complex diseases. The authors' group benefited greatly from the work and efforts of the entire consortium, especially the Coordinating Center (directed by B. Weir and C. Laurie of the University of Washington; U01-HG004446) in data cleaning and preparation for submission to the Database for Genotypes and Phenotypes (dbGaP). The authors also acknowledge the leadership of T. Manolio of NHGRI and E. Harris of National Institute of Dental and Craniofacial Research (NIDCR). Genotyping services were provided by the Center for Inherited Disease Research (CIDR). The International Cleft Consortium including genotyping and analysis was supported by the National Institute for Dental and Craniofacial Research through U01-DE-018993; "International Consortium to Identify Genes & Interactions Controlling Oral Clefts", 2007-2009; TH Beaty, PI. TW was supported by the International Collaborative Genetics Research Training Program (ICGRTP), NIH D43 TW06176 and 81102178 from National Natural Science of China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.