Journal article
Gene-environment interaction among GSTT1, PON2 polymorphisms and organic solvents on gestational age in a Chinese women cohort
S Li, K Fang, W Wang, Y Hu, D Chen
Journal of Assisted Reproduction and Genetics | SPRINGER/PLENUM PUBLISHERS | Published : 2014
Abstract
Purpose: To investigate interactions on gestational age among two environmental risk factors and four maternal genetic polymorphisms: organic solvents, passive smoking, CYP1A1 rs4646903 (MspI), EPHX1 rs2234922 (His139Arg), GSTT1 and PON2 rs12026 (Ala148Gly). Methods: A pregnant women cohort was conducted at Beijing Yanshan Petrochemical Corporation, and 1,097 mothers with live singleton births were included in analysis. Generalized Multifactor Dimensionality Reduction (GMDR) method was used to explore interactions among these factors with adjustment for important potential confounders. Multiple linear regression models were used to estimate the association of interaction with gestational age..
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Awarded by National Institute of Environmental Health Sciences
Funding Acknowledgements
We sincerely thank all of the participants and their families for participating in this study, and we gratefully acknowledge the invaluable assistance of clinical, field and laboratory staff who contributed to making this work possible. This study is supported in part by grants R825818 from the Environmental Protection Agency, 1R01 HD32505-01 from the National Institute of Child Health and Human Development, 1R01 ES08337-01 from the National Institute of Environmental Health Science and 1R01 OH03027 from the National Institute of Occupational Safety and Health.