Journal article
Non-response to (statin) therapy: The importance of distinguishing non-responders from non-adherers in pharmacogenetic studies
S Trompet, I Postmus, PE Slagboom, BT Heijmans, RAJ Smit, AB Maier, BM Buckley, N Sattar, DJ Stott, I Ford, RGJ Westendorp, AJM De Craen, JW Jukema
European Journal of Clinical Pharmacology | SPRINGER HEIDELBERG | Published : 2016
Abstract
Purpose: In pharmacogenetic research, genetic variation in non-responders and high responders is compared with the aim to identify the genetic loci responsible for this variation in response. However, an important question is whether the non-responders are truly biologically non-responsive or actually non-adherent? Therefore, the aim of this study was to describe, within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), characteristics of both non-responders and high responders of statin treatment in order to possibly discriminate non-responders from non-adherers. Methods: Baseline characteristics of non-responders to statin therapy (≤10 % LDL-C reduction) were compared ..
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Awarded by European Commission
Funding Acknowledgements
The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. HEALTH-F2-2009-223004. This work was performed as part of an ongoing collaboration of the PROSPER study group in the universities of Leiden, Glasgow, and Cork. Prof. Dr. J.W. Jukema is an established clinical investigator of The Netherlands Heart Foundation (2001 D 032).