Journal article
IL7R gene expression network associates with human healthy ageing
WM Passtoors, EB van den Akker, J Deelen, AB Maier, R van der Breggen, R Jansen, S Trompet, D van Heemst, E Derhovanessian, G Pawelec, GJB van Ommen, PE Slagboom, M Beekman
Immunity and Ageing | BIOMED CENTRAL LTD | Published : 2015
Abstract
Background: The level of expression of the interleukin 7 receptor (IL7R) gene in blood has recently been found to be associated with familial longevity and healthy ageing. IL7R is crucial for T cell development and important for immune competence. To further investigate the IL7R pathway in ageing, we identified the closest interacting genes to construct an IL7R gene network that consisted of IL7R and six interacting genes: IL2RG, IL7, TSLP, CRLF2, JAK1 and JAK3. This network was explored for association with chronological age, familial longevity and immune-related diseases (type 2 diabetes, chronic obstructive pulmonary disease and rheumatoid arthritis) in 87 nonagenarians, 337 of their midd..
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Awarded by Centre for Medical Systems Biology
Funding Acknowledgements
We thank all participants of the Leiden Longevity Study. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no 259679 (IDEAL) and no HEALTH-F2-2009-223004. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology (CMSB) [http://www.cmsb.nl], the Netherlands Consortium for Healthy Ageing (NCHA, Grant 050-060-810) [http://www.healthy-ageing.nl], all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO) and by Unilever Colworth. The funders had no role in study design, data collection and analysis, decision to publish or the preparation of the manuscript.