Journal article

CCR4( ) Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

Evelyna Derhovanessian, Sijia Chen, Andrea B Maier, Karin Haehnel, Anton JM de Craen, Helene Roelofs, Rudi Westendorp, Graham Pawelec

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | OXFORD UNIV PRESS INC | Published : 2015

Abstract

CD4(+) regulatory T cells (Tregs) are a distinct population of T cells involved in maintaining peripheral tolerance to self-antigens. Several studies have shown increased frequency and number of Tregs in the elderly. Whether such an increase has any clinical relevance has not been addressed. Here, we have analyzed circulating Tregs in 114 donors between the ages of 18 and 89 years and assessed their implications for survival of the very elderly. In line with previously published data, we observed higher proportions of Tregs in the elderly. Expression of chemokine receptor 4 (CCR4) by Tregs has been shown to characterize antigen-primed activated Tregs with immediate suppressive function. Thus..

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Grants

Awarded by European Commission


Awarded by German Research Foundation


Awarded by Federal Ministry of Education and Research


Awarded by Innovation Oriented Research Program on Genomics


Awarded by Centre for Medical Systems Biology, and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research


Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO)


Awarded by Netherlands Consortium for Healthy Aging


Funding Acknowledgements

This work was supported by the European Commission (FP6 036894 "LifeSpan"; FP7 259679 "IDEAL"); German Research Foundation (DFG-PA 361/14-1); and the Federal Ministry of Education and Research (0315890F "Gerontoshield"). The Leiden Longevity Study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007); the Centre for Medical Systems Biology, and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (05040202 and 050-060-810). The Leiden 85+ study was funded by the Program Translational Research of the Netherlands organization for health research and development, the Leiden University Fund, and by an unrestricted grant from the Netherlands Organization of Scientific Research (ZonMw), the Ministry of Health, Welfare and Sports, and the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810 Netherlands Consortium for Healthy Aging).